Publications

Title :Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier Abstract : Background: Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of the […]

Title : Comparative transcriptomics approach in elucidation of carotenoid biosynthesis regulation in grains of rice (OryzasativaL.) Abstract : Background: Estimation of phytoene, lycopene, β-carotene, lutein, and zeaxanthin in grains of white, brown and purple cultivars of rice revealed marked differences in the levels of these carotenoid intermediates amongst the cultivars. Grains of white rice did […]

Title : A transcriptomic snapshot of early molecular communication between Pasteuriapenetransand Meloidogyne incognita Abstract : Background: Southern root-knot nematode Meloidogyne incognita (Kofoid and White, 1919), Chitwood, 1949 is a key pest of agricultural crops. Pasteuriapenetrans is a hyperparasitic bacterium capable of suppressing the nematode reproduction, and represents a typical coevolved pathogen-hyperparasite system. Attachment of Pasteuria […]

Title : Unraveling the role of aurora A beyond centrosomes and spindle assembly: implications in muscle differentiation. Abstract : Aurora kinases are critical mitotic serine/threonine kinases and are often implicated in tumorigenesis. Recent studies of the interphase functions for aurora kinase (Aurk)A have considerably expanded our understanding of its role beyond mitosis. To identify the […]

Title : Probiotics L. acidophilus and B. clausii Modulate Gut Microbiota in Th1- and Th2-Biased Mice to Ameliorate Salmonella Typhimurium-Induced Diarrhea. Abstract : Gut microbiota play important role in maintaining health. Probiotics are believed to augment it further. We aimed at comparing effects of probiotics, Lactobacillus acidophilus (LA) and Bacillus clausii (BC) (a) on the […]

Title : ARMOUR – A Rice miRNA: mRNA Interaction Resource. Abstract : ARMOUR was developed as A Rice miRNA:mRNA interaction resource. This informative and interactive database includes the experimentally validated expression profiles of miRNAs under different developmental and abiotic stress conditions across seven Indian rice cultivars. This comprehensive database covers 689 known and 1664 predicted […]

Title: Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection. Abstract : Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis of E. anopheles endophthalmitis strain surprisingly found from an eye infection patient with twenty-five other E. anophelis […]

Title : Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress. Abstract : Research on toxin-antitoxin loci (TA loci) is gaining impetus due to their ubiquitous presence in bacterial genomes and their observed roles in stress survival, persistence and drug tolerance. The present study investigates the expression profile of […]

Title : Biological and regulatory rolesof acid-induced small RNA RyeC in Salmonella Typhimurium. Abstract : Salmonella Typhimurium is an enteric pathogen that has evolved masterful strategies to enable survival under stress conditions both within and outside a host. The acid tolerance response (ATR) is one such mechanism that enhances the viability of acid adapted bacteria […]

Title : Draft Genome Sequence of Multidrug-Resistant Escherichia coli NIVEDI-P44, Isolated from a Chicken Fecal Sample in Northeast India. Abstract : We report here the draft genome sequence of a multidrug-resistant Escherichia coli strain (NIVEDI-P44) isolated from a chicken fecal sample. The estimated genome size is 4.76 Mb, with a G+C content of 50.65%. The […]

Title : Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Abstract : Rudhira/Breast Carcinoma Amplified Sequence 3 (BCAS3) is a cytoskeletal protein that promotes directional cell migration and angiogenesis in vitro and is implicated in human carcinomas and coronary artery disease. To study the role of Rudhira during development in vivo, we generated the […]

Title : p53 mediated regulation ofcoactivator associated arginine methyltransferase 1 (CARM1) expression iscritical for suppression of adipogenesis. Abstract : Coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) is a type I arginine methyltransferase that mediates transcriptional activation via methylation of histone H3 on R17, R26, and R42. CARM1 is also a coactivator of transcription of various transcription factors […]

Title : Characterization andMolecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2Interaction in Retinoblastoma. Abstract: Inhibition of the interaction between p53 and HDM2 is an effective therapeutic strategy in cancers that harbor a wild-type p53 protein such as retinoblastoma (RB). Nanoparticle-based delivery of therapeutic molecules has been shown to be advantageous in localized delivery, including to […]

Title : Global microRNA expressionprofiling in the liver biopsies of hepatitis B virus-infected patients suggestsspecific microRNA signatures for viral persistence and hepatocellular injury. Abstract : Hepatitis B virus (HBV) can manipulate the microRNA (miRNA) regulatory networks in infected cells to create a permissive environment for viral replication, cellular injury, disease onset, and its progression. The […]

Title : Draft Genome Sequence of Rhizoctonia solani Anastomosis Group 1 Subgroup 1AStrain 1802/KB Isolated from Rice. Abstract : Sheath blight, caused by Rhizoctonia solani anastomosis group 1 subgroup 1A (AG1-1A), is one of the most devastating rice diseases worldwide. Here, we report the draft genome sequence of R. solani AG1-1A strain 1802/KB isolated from […]

Title : Identification of functionally important microRNAs from rice inflorescence at heading stage of a qDTY4.1-QTL bearing Near Isogenic Line under drought conditions. Abstract : A cross between IR64 (high-yielding but drought-susceptible) and Aday Sel (drought-tolerant) rice cultivars yielded a stable line with enhanced grain yield under drought screening field trials at International Rice Research […]

Title : Co-expressionnetwork analysis of toxin-antitoxin loci in Mycobacterium tuberculosis revealskey modulators of cellular stress. Abstract : Research on toxin-antitoxin loci (TA loci) is gaining impetus due to their ubiquitous presence in bacterial genomes and their observed roles in stress survival, persistence and drug tolerance. The present study investigates the expression profile of all the […]

Guest lecture on “Applications of Next Generation Sequencing in Healthcare ” by Dr. Raman Govindarajan.

Title: miRNA signatures can predict acute liver failure in hepatitis E infected pregnant females Abstract: Acute viral hepatitis E (AVH-E) can often result in acute liver failure (ALF) during pregnancy. microRNAs serve as mediators in drug induced liver failure. We investigated their role as a biomarker in predicting ALF due to HEV (ALF-E). FINDINGS: Eleven […]

TITLE: Gene regulatory networking reveals the molecular cue to lysophosphatidic acid-induced metabolic adaptations in ovarian cancer cells. ABSTRACT: Extravasation and metastatic progression are two main reasons behind the high mortality rate associated with cancer. The metastatic potential of cancer cells depends on a plethora of metabolic challenges prevailing in the tumor microenvironment. To achieve higher proliferative rates, […]

Title: EpCAM+ Liver Cancer Stem-Like Cells Exhibiting Autocrine Wnt Signaling Potentially Originate in Cirrhotic Patients. Abstract: Hepatocellular carcinoma (HCC) is believed to originate from cancer stem cells (CSCs). While epithelial cell adhesion molecule (EpCAM) is a marker of normal hepatic stem cells (HSCs), EpCAM+ cells from HCC behave like CSCs. Since HCC mostly develops on […]

TITLE: Age-related changes in gene expression patterns of immature and aged rat primordial follicles. ABSTRACT: Women are born with millions of primordial follicles which gradually decrease with increasing age and this irreversible supply of follicles completely exhausts at menopause. The fertility capacity of women diminishes in parallel with aging. The mechanisms for reproductive aging are […]

TITLE: Transcriptional changes during ovule development in two genotypes of litchi (Litchi chinensis Sonn.) with contrast in seed size ABSTRACT: Litchi chinensis is a subtropical fruit crop, popular for its nutritional value and taste. Fruits with small seed size and thick aril are desirable in litchi. To gain molecular insight into gene expression that leads to […]

TITLE: Transcriptome Analysis of the Response to NaCl in Suaeda maritima Provides an Insight into Salt Tolerance Mechanisms in Halophytes ABSTRACT: Although salt tolerance is a feature representative of halophytes, most studies on this topic in plants have been conducted on glycophytes. Transcriptome profiles are also available for only a limited number of halophytes. Hence, […]

TITLE: Nucleolin-aptamer therapy in retinoblastoma: molecular changes and mass spectrometry–based imaging ABSTRACT: Retinoblastoma (RB) is an intraocular childhood tumor which, if left untreated, leads to blindness and mortality. Nucleolin (NCL) protein which is differentially expressed on the tumor cell surface, binds ligands and regulates carcinogenesis and angiogenesis. We found that NCL is over expressed in […]

TITLE: De novo Assembly of Leaf Transcriptome in the Medicinal Plant Andrographis paniculata   ABSTRACT: Andrographis paniculata is an important medicinal plant containing various bioactive terpenoids and flavonoids. Despite its importance in herbal medicine, no ready-to-use transcript sequence information of this plant is made available in the public data base, this study mainly deals with […]

TITLE: Notch1-MAPK Signaling Axis Regulates CD133+ Cancer Stem Cell-Mediated Melanoma Growth and Angiogenesis ABSTRACT: Functional characterization and understanding of the intricate signaling mechanisms in stem like cells is crucial for the development of effective therapies in melanoma. We have studied whether melanoma cells are phenotypically distinct and hierarchically organized according to their tumorigenic nature. We […]

Title: Draft Genome Sequence of Acinetobacter sp. Strain BMW17, a Cellulolytic and Plant Growth-Promoting Bacterium Isolated from the Rhizospheric Region of Phragmites karka of Chilika Lake, India   Genome Announcement:  We report the 3.16 Mb draft genome of Acinetobacter sp. strain BMW17, a Gram-negative bacterium in the class of Gammaproteobacteria, isolated from the rhizospheric region […]

Integrated Analysis of Dysregulated miRNA-gene Expression in HMGA2-silenced Retinoblastoma Cells

Genome wide screening of RNAi factors of Sf21 cells reveal several novel pathway associated proteins.

Dramatic Changes in 67 MicroRNAs During Initiation of First Wave of Spermatogenesis in Mus musculus Testis:Global Regulatory Insights Generated by MicroRNA-mRNA Network Analysis.

Gene expression analysis of laminin‐1‐induced neurite outgrowth in human mesenchymal stem cells derived from bone marrow

Epigenetic response in mice mastitis: Role of histone H3 acetylation and microRNA(s) in the regulation of host inflammatory gene expression during Staphylococcus aureus infection

A draft genome assembly of the army worm, Spodoptera frugiperda

De novo transcriptome sequencing and analysis of the cereal cyst nematode, Heterodera avenae.

A new microarray platform for whole-genome expression profiling of Mycobacterium tuberculosis.

Mitochondria Influence CDR1 Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans.

Identification and Insilico Analysis of Retinoblastoma Serum microRNA Profile and Gene Targets Towards Prediction of Novel Serum Biomarkers.

Identification of tissue-preferential expression patterns of rice miRNAs

Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene expression Analysis

Probing p300/CBP Associated Factor (PCAF)-Dependent Pathways with a Small Molecule Inhibitor

RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastoma.

The interplay of HuR and miR-3134 in regulation of AU rich transcriptome

Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.

Differential Expression of Genes Involved in Early Events of Spermatogenesis in Mice

Nuclear factor (NF)-κB and its associated pathways are major molecular regulators of blood-induced joint damage in a murine model of hemophilia.

Gene expression profiles and retinal potential of stem/progenitor cells derived from human iris and ciliary pigment epithelium.

Pyrosequencing-Based Transcriptome Analysis of the Asian Rice Gall Midge Reveals Differential Response during Compatible and Incompatible Interaction

Microarray analysis and biochemical correlations of oxidative stress responsive genes in retinoblastoma.

Histone H3K14 and H4K8 hyperacetylation is associated with Escherichia coli-induced mastitis in mice.